Enantioselective hydrolysis of racemic naproxen nitrile and naproxen amide to S-naproxen by new bacterial isolates
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Enantioselective hydrolysis of racemic naproxen nitrile and naproxen amide to S-naproxen by new bacterial isolates.
Bacteria were enriched from soil samples with succinate as a carbon source and racemic naproxen nitrile [2-(6-methoxy-2-naphthyl)propionitrile] as sole source of nitrogen. Since naproxen nitrile was only poorly soluble in water media amended with different water-immiscible organic phases were used for the enrichments. With pristane (2,6,10,14-tetramethylpentadecane) as the organic phase two bac...
متن کاملEnzyme-catalysed enantioselective hydrolysis of racemic naproxen nitrile.
The bacterial strain Rhodococcus butanica (ATCC 21197), which exhibits nitrilase and nitrile hydratase/amidase activities, catalyses the enantioselective hydrolysis of racemic naproxen nitrile (R/S)-1 to furnish a moderate enantiomeric excess of (S)-naproxen (S)-3. Racemic naproxen amide (R/S)-2 is not a good substrate for this strain. Resting cells of the newly selected bacterial strain Rhodoc...
متن کاملScreening of commercial enzymes for the enantioselective hydrolysis of R,S-naproxen ester
This study focused on the identification of suitable lipase or esterase activity for enantiomeric resolution of (R,S)-naproxen. For an economically viable reaction the enantiomeric ratio (E) should preferably be >100, while maximising the conversion will reduce the mass of material that requires racemisation and recycling. Hence the aim was to find an enzyme that yields (S)-naproxen with an ena...
متن کاملAsymmetrische Katalyse, 134 [1]. Naproxen-Derivate durch enantioselektive Decarboxylierung Asymmetric Catalysis, 134 [1]. Naproxen Derivatives by Enantioselective Decarboxylation
2-Aryl-substituted propionic acids, such as the important anti-inflammatory agent Naproxen, exist in two enantiomeric forms. The (S^-enantiomer of 2-(6-methoxynaphth-2-yl)propionic acid 1 is about 28 times more effective than the (/?)-enantiomer. A new catalytic method to synthesize Naproxen (S)-l involves the enantioselective decarboxylation of suitably substi tuted malonic acid derivatives. ...
متن کاملNaproxen-associated vasculitis.
Three cases of digital vasculitis attributable to naproxen ingestion are reported. The vasculitic changes were reversed by withdrawal of the drug. These three cases emphasize the need to consider drug sensitivity as a cause of unexplained digital vascular lesions.
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ژورنال
عنوان ژورنال: Journal of Biotechnology
سال: 1994
ISSN: 0168-1656
DOI: 10.1016/0168-1656(94)90109-0